June 23, 2025

The global blister packaging market is worth over $18 billion and experts predict it will hit $28 billion by 2022. But what exactly is blister packaging? Picture a budget-friendly packaging option that uses a preformed plastic pocket or shell heat-sealed to paperboard or foil backing.

The pharmaceutical industry’s creation from the 1960s has grown way beyond its original uses. This versatile packaging now serves industries of all types – from pharmaceuticals and electronics to cosmetics, hardware, toys, and household goods. Manufacturers love blister packaging because it keeps products clean and uncontaminated while letting customers see what they’re buying. The numbers tell the story – billions of blister packs roll off production lines each year. This is a big deal as it means that blister packs rank among the most budget-friendly ways to package products.

Let’s get into the basics of blister packaging types in this piece. You’ll find what goes into making them and see how different manufacturers put them to work. This guide has everything your manufacturing team needs to know, whether you’re just starting out or looking to make your current processes better.

Understanding Blister Packaging and Its Core Components

Blister packaging uses two key parts that protect products and keep them visible. The system combines a shaped plastic shell (the blister) with backing material to hold products securely.

Blister Cavity: Thermoformed Plastic Shell

The blister cavity serves as the main protective element. Manufacturers create it through thermoforming, where plastic sheets become soft and moldable under heat. The plastic moves to a forming station after reaching the right temperature. High pressure (4 to 8 bar) shapes it against a negative mold. The mold cools down to help the plastic harden and keep its shape.

Products with complex shapes need an “assist plug” to maintain consistent wall thickness throughout. The cavity’s shape matches the product’s contours with small gaps that prevent impact damage and hold items securely. This precise molding creates perfect pockets for tablets, electronics, and consumer goods.

Lidding Materials: Foil, Film, and Paperboard

Several types of lidding materials seal products into the blister cavity:

• Aluminum Foil: Pharmaceutical companies prefer this material because it blocks moisture, oxygen, and UV light effectively. Aluminum foil’s different tempers include:
  • Soft-tempered foil: Better for packaging hard items like tablets
  • Hard-tempered foil: Breaks easily with enough force, perfect for push-through packs
• PET (Polyethylene Terephthalate): Works well with other materials to boost protection
• Paper/Paperboard: Provides economical solutions and printable backing options

Lidding structures come in three types: Push-Through-Packs (PTP) that break under pressure, peelable lids you can remove without damaging the pocket, or hybrid designs with both features. Pharmaceutical lidding foil usually has heat-seal lacquer inside and print primer outside.

Common Materials: PVC, PET, and Aluminum Foil

PVC (Polyvinyl Chloride) leads the blister packaging industry with 95% market share. Companies choose it for its low cost, clarity, and easy thermoforming properties. PVC also resists chemicals well and provides good barrier protection. Forming film thickness ranges from 0.2 to 0.3 millimeters.

PET (Polyethylene Terephthalate) stands out as a greener option than PVC. Notwithstanding that, PET lets more water vapor through than PVC, which limits its use in pharmaceuticals without extra barriers.

Aluminum foil works both as a lid and structure in cold-formed blister packaging. Cold forming creates blister cavities by pressing aluminum-based laminate film into molds without heat. This method blocks moisture, oxygen, and light perfectly, making it great for sensitive medicines that need long shelf life.

Products needing maximum protection use advanced barrier materials such as:

• PVDC (Polyvinylidene Chloride) coating on PVC to make moisture and oxygen barriers 5-10 times better
• PCTFE (Polychlorotrifluoroethylene) laminated over PVC to create superior moisture protection
• Cyclic olefin copolymers (COC) mixed with other polymers to form deeper, more secure cavities

Product sensitivity, barrier needs, costs, and environmental impact help determine the best materials to use.

Types of Blister Packaging by Structure and Material

Blister packaging designs come in many forms, each with unique advantages that suit different product needs. Manufacturing teams should know these variations to pick the right format that matches their application requirements.

Face Seal vs Full-Face Seal Blisters

Face seal blisters are the most cost-effective and common type of blister packaging. The design uses a flanged plastic blister around the product that heat-seals to a paperboard backing card. The seal only happens on the flange while the card’s remaining area stays uncovered. This format suits lightweight products like lip balms, sewing notions, and writing instruments.

Full-face seal blisters cover the entire front face of the package with a plastic blister. This design creates a more durable package that protects the card edges and strengthens any hanger feature by covering the whole blister card. Full-face seals work best for heavier products and give a higher perceived value, though they cost more.

Trapped and Slide Blisters

Trapped blisters use two printed cards—front and back. The front card has a die-cut hole where the blister shape comes through, with the flange sealed between both cards. This setup makes products highly secure and almost impossible to steal. The plastic sits between two paperboard pieces, which removes the need for expensive heat-seal tooling. High-value products that need improved tamper resistance often use this design.

Slide blisters have three wrap-around edges and an open end where the header card slides in. These packages often need staples or tape for security but don’t require heat sealing or gluing. The card’s easy removal and replacement make this design reusable.

Clamshell and Tri-Fold Variants

Clamshell packaging has two halves that connect like a clam’s shell. This resilient format protects heavy products well. Manufacturers can seal clamshells using heat, radio frequency, or UV light for tamper resistance, or add snap-shut buttons for reuse. Though they offer better protection, clamshells cost more and need complex tooling.

Tri-fold clamshells use two hinges that create a wide triangular bottom when folded. Products with unstable or odd shapes stay secure in this design. Retailers can display these packages standing upright or hanging, thanks to the tri-fold structure.

Pharmaceutical Blister Packaging Formats

Pharmaceutical products need special blister formats that meet strict standards:

• Thermoform blister packaging: Pharmaceutical companies commonly use this format. It employs heated plastic forming film (usually PVC or variants) that shapes into cavities through mechanical press or vacuum forming. These see-through packages let you inspect products and keep costs low.
• Cold form blister packaging: This format, also called “Alu-Alu” packaging, uses aluminum-based laminate pressed into cavities without heat. The structure combines oriented polyamide, aluminum foil, and PVC layers to protect moisture and light-sensitive drugs.
• Specialty formats: These include calendar packs (showing days/times for dosing), peel-push packs (for people with limited hand strength), and child-resistant designs that need specific opening sequences.

Each blister packaging type brings specific benefits that help manufacturers balance protection, visibility, cost, and user experience needs.

Blister Packaging Manufacturing Processes Explained

Manufacturing teams use three main methods to produce blister packaging. Each method provides specific advantages for product protection and production volumes.

Thermoforming: Heating and Molding Plastic Sheets

Thermoforming is accessible to more people as a blister packaging process because it’s simple and handles high volumes well. The process starts as clear PVC sheets move between upper and lower heating plates. These plates warm the material to its forming temperature—just above its glass transition point. The plastic becomes pliable without melting completely. The sheet then moves to the forming station where it takes shape using two main methods:

• Vacuum forming: The heated sheet drapes over a mold while a vacuum system pulls air out to create the desired shape
• Pressure forming: The material gets pushed into the mold under pressure (typically 4-8 bar), sometimes using a plug-assist feature that ensures even wall thickness

Refrigerated plates cool the formed plastic faster, which helps it become rigid and keep its shape. A precision die cutter then trims the formed blisters to their final size. Complex designs need mechanical stamps to create intricate details during forming.

Cold Forming: Aluminum-Based Barrier Packaging

Cold forming takes a different path and doesn’t use heat. The process uses thin sheets of aluminum-based laminate film (typically OPA-ALU-PVC structure). These sheets are mechanically pressed into cavity shapes with a negative die and positive plug. The aluminum changes shape permanently after stamping.

This method creates packaging that blocks almost all moisture (virtually 0g/m²/day water vapor transfer rate), oxygen, and light. It’s perfect for pharmaceuticals that need a long shelf life. Cold forming works best for moisture-sensitive and light-sensitive products, even though it gets pricey and runs slower.

The standard cold-form structure uses oriented polyamide (25-30 microns), aluminum (45-60 microns), and PVC (60-100 microns). The total thickness ranges from 135-200 microns.

Thermo Cold Forming: Dual-Layer Protection

Thermo cold forming is an innovative hybrid that combines both previous methods’ benefits. The process creates a transparent inner layer through thermoforming, then adds a cold-formed aluminum outer layer.

Products first get wrapped in a thermoformed plastic shell that shows the contents and provides structure. An aluminum layer then forms around this inner package. This dual-layer system offers maximum barrier protection. The final product lets you see what’s inside while protecting it from environmental factors.

This technique is a great way to get value for high-sensitivity pharmaceutical products. These products need to stay visible but also need complete protection from moisture, oxygen, and light. Thermo cold forming might be more complex and expensive than single methods, but it’s perfect for products needing both display features and longer shelf life.

Applications Across Industries and Use Cases

Blister packaging plays unique roles in many industries. Each sector takes advantage of this versatile packaging method’s benefits. The applications keep growing as manufacturing technologies get better.

Pharmaceuticals: Tamper-Evident and Dosed Packaging

Pharmaceutical companies use blister packaging for tablets, capsules, and syringes. These packs’ individual compartments protect medications from contamination and help patients track their doses. Many pharmaceutical blisters show days of the week to help patients take their medicine correctly. The tamper-evident design keeps patients safe and meets healthcare industry’s legal standards. Some medications need extra protection, so manufacturers add child-resistant features that work at specific pressure angles – tough for kids but easy for adults to manage. The compartments in these packs let healthcare providers track patient usage through cloud-connected systems. Get a free quote for Medicine packaging to learn about your pharmaceutical product options.

Electronics: Theft-Resistant and Display-Ready Packs

Electronics companies use blister packaging to protect items from damage and theft. Products like flash drives, batteries, and accessories come in clamshell blister formats that you can’t open without the right tools. Yes, it is harder for shoplifters to hide these irregularly shaped packages. The clear plastic shell lets customers see products completely before buying, so there’s no need to open packages in stores. This mix of visibility and security makes blister packaging perfect for small, expensive electronics that need both protection and visual appeal.

Food and Personal Care: Shelf Life and Hygiene Benefits

The food industry uses blister packaging for snacks like candy, chewing gum, and chocolates. A sealed environment keeps food items dry and fresh longer. Personal care products like makeup brushes, mascara wands, and razors stay hygienic and maintain quality in blister packs. Customers feel more confident when they can see the products, and the protective barrier keeps them clean before use. These packages work great for small personal care items that sell quickly, offering budget-friendly solutions with good looks.

Advantages and Limitations for Manufacturing Teams

Manufacturing teams must understand both advantages and limitations to get the complete picture of what is blister packaging.

Product Visibility and Branding Opportunities

Blister packaging provides exceptional product visibility that affects consumer buying decisions. Customers can see products through the transparent design without opening the package. This builds trust and leads to fewer returns from mismatched expectations. The packaging surface gives plenty of room to print important details like dosage instructions, expiry dates, and brand logos. These features help pharmaceutical companies boost their brand presence.

Product perception changes by a lot with quality blister packaging. A well-laid-out, user-friendly package keeps products safe and builds brand trust—everything in industries where consumer confidence matters most. Brands can customize shapes and add glossy finishes, quality graphics, and bright colors. These elements create a distinctive shelf presence that strengthens brand identity.

Cost Efficiency in High-Volume Production

The original investment in blister packaging equipment might be high, but long-term benefits make it worthwhile. Automation drives most of the production process, which cuts labor costs and speeds up production. The lightweight nature of blister packs also reduces shipping costs compared to other packaging methods.

Blister packaging shows remarkable efficiency in high-volume production through:

• Less material use compared to bottles or boxes
• Smaller storage space needs
• Lower product waste with individual compartments

Material Waste and Recycling Challenges

Blister packaging creates major environmental challenges. Traditional blister packs mix plastic and aluminum, which makes them too complex for normal recycling processes. Millions of tons of blister packs end up in landfills or get incinerated each year because of this.

Special processes separate plastic and aluminum components to recycle blister packaging. Technologies that use hydrometallurgical or thermal processes exist, but limited availability makes blister pack recycling harder than it should be to discover eco-friendly options that protect products while staying sustainable.

The Future of Blister Packaging in Modern Manufacturing

This piece explores what blister packaging really covers. Blister packaging started modestly in 1960s pharmaceuticals and has grown into an $18 billion global industry. The packaging solution’s versatility has made it a game-changer in multiple sectors.

Manufacturing teams definitely need to understand the core components that make this packaging work. These include thermoformed plastic shells and various lidding materials. The different structural types (face seal, full-face seal, trapped, clamshell) protect almost any product. Three main manufacturing methods—thermoforming, cold forming, and thermo cold forming—give teams flexibility based on their product’s sensitivity needs.

Blister packaging’s versatility shines through its wide use in pharmaceuticals, electronics, food, and personal care industries. Pharmaceutical applications showcase tamper-evidence and dosage tracking benefits. Electronics manufacturers love the theft resistance and product visibility. Food and personal care companies get extended shelf life and better hygiene.

Manufacturing teams should weigh the most important advantages against key limitations. Product visibility, branding opportunities, and cost efficiency in high-volume production are great benefits. But these advantages need balancing against environmental concerns about material waste and recycling challenges.

Blister packaging will without doubt keep evolving as manufacturers develop green materials and better recycling technologies. Smart companies now look into biodegradable alternatives and mono-material structures. These solutions help tackle environmental concerns while protecting products effectively.

Manufacturing teams that want to improve their packaging strategy can rely on blister packaging when they implement it right. The future looks bright as breakthroughs push this packaging toward greener practices without losing the protection and visibility that made it a soaring win.